Altered miRNA expression in T regulatory cells in course of multiple sclerosis.
作者： Giuseppe De Santis , Manuela Ferracin , Andrea Biondani , Luisa Caniatti , Maria Rosaria Tola
DOI: 10.1016/J.JNEUROIM.2010.06.009
关键词: Immunology 、 Chronic inflammatory response 、 Multiple sclerosis 、 T cell 、 Regulation of gene expression 、 Autoimmunity 、 IL-2 receptor 、 Immune system 、 Transforming growth factor beta 、 Biology
摘要: article i nfo Objectives: Multiple sclerosis (MS) is a chronic inflammatory response against constituents of the central nervous system. It known that regulatory T cells (Tregs) play key role in autoimmune balance and their improper function may facilitate expansion autoaggressive cell clones. Recently, microRNAs (miRNAs) have been involved disorders loss-of-function immune was shown to systemic disorders. Here, we analyzed miRNA expression profile Tregs from MS-RR. Methods: We assessed genome-wide by microarray analysis on CD4 + CD25 +high Tc ells
core.ac.uk
unifi.it
elsevier.com
sci-hub.se 参考文章(40)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Kulkarni Ab, Karlsson S, Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. American Journal of Pathology. ,vol. 143, pp. 3- 9 ,(1993)
Satoshi Yamagiwa, J. Dixon Gray, Shigeo Hashimoto, David A. Horwitz, A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood The Journal of Immunology. ,vol. 166, pp. 7282- 7289 ,(2001) , 10.4049/JIMMUNOL.166.12.7282
Massimo C. Fantini, Christoph Becker, Giovanni Monteleone, Francesco Pallone, Peter R. Galle, Markus F. Neurath, Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. Journal of Immunology. ,vol. 172, pp. 5149- 5153 ,(2004) , 10.4049/JIMMUNOL.172.9.5149
Song Guo Zheng, Ju Hua Wang, William Stohl, Kyoung Soo Kim, J. Dixon Gray, David A. Horwitz, TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells Journal of Immunology. ,vol. 176, pp. 3321- 3329 ,(2006) , 10.4049/JIMMUNOL.176.6.3321
Song Guo Zheng, Ju Hua Wang, J. Dixon Gray, Harold Soucier, David A. Horwitz, Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10 Journal of Immunology. ,vol. 172, pp. 5213- 5221 ,(2004) , 10.4049/JIMMUNOL.172.9.5213
Todd S. Davidson, Richard J. DiPaolo, John Andersson, Ethan M. Shevach, Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells Journal of Immunology. ,vol. 178, pp. 4022- 4026 ,(2007) , 10.4049/JIMMUNOL.178.7.4022
Jeffrey A. Bluestone, Qizhi Tang, Regulatory T-cell physiology and application to treat autoimmunity Immunological Reviews. ,vol. 212, pp. 217- 237 ,(2006) , 10.1111/J.0105-2896.2006.00421.X
Michelle Boehm, Frank J. Slack, MicroRNA control of lifespan and metabolism. Cell Cycle. ,vol. 5, pp. 837- 840 ,(2006) , 10.4161/CC.5.8.2688
Andrea Ventura, Amanda G. Young, Monte M. Winslow, Laura Lintault, Alex Meissner, Stefan J. Erkeland, Jamie Newman, Roderick T. Bronson, Denise Crowley, James R. Stone, Rudolf Jaenisch, Phillip A. Sharp, Tyler Jacks, Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters Cell. ,vol. 132, pp. 875- 886 ,(2008) , 10.1016/J.CELL.2008.02.019