Speed of Healing and Symptom Relief in Grade II to IV Gastroesophageal Reflux Disease: A Meta-Analysis
作者： N Chiba , CJ De Gara , JM Wilkinson , RH Hunt
DOI: 10.1053/GAST.1997.V112.PM9178669
关键词: Gastroenterology 、 Esophageal disease 、 Heartburn 、 Drug class 、 Meta-analysis 、 Internal medicine 、 GERD 、 Reflux 、 Esophagitis 、 Stretta procedure 、 Medicine
摘要: Abstract BACKGROUND & AIMS: Esophagitis healing proportions are often incorrectly called the rate. The aim of this study was to compare different drug classes by expressing speed and symptom relief through a new approach. METHODS: A fully recursive literature search July 1996 identified 43 articles on gastroesophageal reflux disease (GERD) (7635 patients) meeting strict inclusion criteria: single- or double-blind randomized studies in adults with endoscopically proven erosive ulcerative esophagitis. For each class, linear regression analysis estimated average percentage patients who were healed heartburn free per week. RESULTS: Mean overall proportion irrespective dose treatment duration (
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