The immunologic effects of estrogen on psoriasis: A comprehensive review

摘要: Abstract Background Immunological changes in pregnancy are associated with improvements some pre-existing immune-mediated skin diseases. Estrogen has been hypothesized to contribute these by creating a shift from Th1 and Th17 Th2 immunity. As this hypothesis would predict, psoriasis (a primarily mediated immune disease) tends improve during pregnancy. However, the precise mechanism which estrogen induces immunological change remains poorly understood. Objective To summarize immunologic effects of as they relate Methods We performed an English-language PubMed search articles September 2004 2014 combining key terms "psoriasis," "estrogen," "autoimmune disease," "pregnancy." Results appears up-regulate cytokines down-regulate cytokines. This was initially observed murine systems, showed decreased mixed lymphocyte reactions splenocytes increased antibody production Antigen stimulated produced fewer more pregnant mice. IL17 producing T cells were significantly healthy pregnancies compared non-pregnant controls. Limitations review is limited paucity studies evaluating among human subjects. Conclusions Increased cytokine production. While may be responsible for shifts resulting disease improvement, there no definitive evidence prove that such improvement.