Triple vs. quadruple therapy for treating Helicobacter pylori infection: an updated meta-analysis

摘要: Summary Background: Triple therapy (proton pump inhibitor, clarithromycin and amoxicillin or an imidazole) is the first-line treatment for Helicobacter pylori infection. However, effectiveness of triple decreasing due to increase in antibiotic resistance. Quadruple tetracycline, metronidazole a bismuth salt) very effective regimen even areas high prevalence resistance, may be alternative treatment. Aim: To compare vs. quadruple H. infection. Methods: An extensive literature search was performed identify randomized trials comparing therapy. Selected were included meta-analysis using Review Manager 4.1. Results: Four studies met inclusion criteria. Eradication rates with slightly higher both intention-to-treat (81% 78%; odds ratio, 0.83; 95% confidence interval, 0.61–1.14) per protocol (88% 85%; 0.81; 0.55–1.20) analysis, although differences not statistically significant. Nor there significant compliance adverse effects between therapies. Conclusion: therapies seem roughly equivalent terms effectiveness, side-effects profile when administered as