Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma.
作者： Elena Parmigiani , Verdon Taylor , Claudio Giachino
DOI: 10.3390/CELLS9102304
关键词: Glioma 、 Tissue homeostasis 、 RBPJ 、 Carcinogenesis 、 Neural stem cell 、 Biology 、 ASCL1 、 Cancer research 、 Notch signaling pathway 、 Brain tumor
摘要: Although the role of NOTCH signaling has been extensively studied in health and disease, many questions still remain unresolved. Being crucial for tissue homeostasis, is also implicated multiple cancers by either promoting or suppressing tumor development. In this review we illustrate context-dependent during tumorigenesis with a particular focus on gliomas, most frequent aggressive brain tumors adults. For long time, considered an oncogene glioma mainly virtue its neural stem cell-promoting activity. However, recent identification NOTCH-inactivating mutations some patients challenged notion, prompting re-examination function subtypes. We discuss findings that might help to reconcile controversial pose outstanding be addressed.
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sci-hub.st 参考文章(165)
Kah Jing Lim, William D. Brandt, Jason A. Heth, Karin M. Muraszko, Xing Fan, Eli E. Bar, Charles G. Eberhart, Lateral inhibition of Notch signaling in neoplastic cells Oncotarget. ,vol. 6, pp. 1666- 1677 ,(2015) , 10.18632/ONCOTARGET.2762
Claudio Giachino, Onur Basak, Sebastian Lugert, Philip Knuckles, Kirsten Obernier, Roberto Fiorelli, Stephan Frank, Olivier Raineteau, Arturo Alvarez-Buylla, Verdon Taylor, Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population STEM CELLS. ,vol. 32, pp. 70- 84 ,(2014) , 10.1002/STEM.1520
Cancer Genome Atlas Research Network, None, Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. The New England Journal of Medicine. ,vol. 372, pp. 2481- 2498 ,(2015) , 10.1056/NEJMOA1402121
J Robbins, B J Blondel, D Gallahan, R Callahan, Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. Journal of Virology. ,vol. 66, pp. 2594- 2599 ,(1992) , 10.1128/JVI.66.4.2594-2599.1992
Allison M. Bond, Guo-li Ming, Hongjun Song, Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later Cell Stem Cell. ,vol. 17, pp. 385- 395 ,(2015) , 10.1016/J.STEM.2015.09.003
Justin D. Lathia, Stephen C. Mack, Erin E. Mulkearns-Hubert, Claudia L.L. Valentim, Jeremy N. Rich, Cancer stem cells in glioblastoma Genes & Development. ,vol. 29, pp. 1203- 1217 ,(2015) , 10.1101/GAD.261982.115
Julie George, Jing Shan Lim, Se Jin Jang, Yupeng Cun, Luka Ozretić, Gu Kong, Frauke Leenders, Xin Lu, Lynnette Fernández-Cuesta, Graziella Bosco, Christian Müller, Ilona Dahmen, Nadine S Jahchan, Kwon-Sik Park, Dian Yang, Anthony N Karnezis, Dedeepya Vaka, Angela Torres, Maia Segura Wang, Jan O Korbel, Roopika Menon, Sung-Min Chun, Deokhoon Kim, Matt Wilkerson, Neil Hayes, David Engelmann, Brigitte Pützer, Marc Bos, Sebastian Michels, Ignacija Vlasic, Danila Seidel, Berit Pinther, Philipp Schaub, Christian Becker, Janine Altmüller, Jun Yokota, Takashi Kohno, Reika Iwakawa, Koji Tsuta, Masayuki Noguchi, Thomas Muley, Hans Hoffmann, Philipp A Schnabel, Iver Petersen, Yuan Chen, Alex Soltermann, Verena Tischler, Chang-min Choi, Yong-Hee Kim, Pierre P Massion, Yong Zou, Dragana Jovanovic, Milica Kontic, Gavin M Wright, Prudence A Russell, Benjamin Solomon, Ina Koch, Michael Lindner, Lucia A Muscarella, Annamaria La Torre, John K Field, Marko Jakopovic, Jelena Knezevic, Esmeralda Castaños-Vélez, Luca Roz, Ugo Pastorino, Odd-Terje Brustugun, Marius Lund-Iversen, Erik Thunnissen, Jens Köhler, Martin Schuler, Johan Botling, Martin Sandelin, Montserrat Sanchez-Cespedes, Helga B Salvesen, Viktor Achter, Ulrich Lang, Magdalena Bogus, Peter M Schneider, Thomas Zander, Sascha Ansén, Michael Hallek, Jürgen Wolf, Martin Vingron, Yasushi Yatabe, William D Travis, Peter Nürnberg, Christian Reinhardt, Sven Perner, Lukas Heukamp, Reinhard Büttner, Stefan A Haas, Elisabeth Brambilla, Martin Peifer, Julien Sage, Roman K Thomas, None, Comprehensive genomic profiles of small cell lung cancer Nature. ,vol. 524, pp. 47- 53 ,(2015) , 10.1038/NATURE14664
Jinlong Yin, Gunwoo Park, Tae Hoon Kim, Jun Hee Hong, Youn-Jae Kim, Xiong Jin, Sangjo Kang, Ji-Eun Jung, Jeong-Yub Kim, Hyeongsun Yun, Jeong Eun Lee, Minkyung Kim, Junho Chung, Hyunggee Kim, Ichiro Nakano, Ho-Shin Gwak, Heon Yoo, Byong Chul Yoo, Jong Heon Kim, Eun-Mi Hur, Jeongwu Lee, Seung-Hoon Lee, Myung-Jin Park, Jong Bae Park, Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells PLOS Biology. ,vol. 13, ,(2015) , 10.1371/JOURNAL.PBIO.1002152
Hyung-song Nam, Robert Benezra, High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells Cell Stem Cell. ,vol. 5, pp. 515- 526 ,(2009) , 10.1016/J.STEM.2009.08.017
O. Ehm, C. Goritz, M. Covic, I. Schaffner, T. J. Schwarz, E. Karaca, B. Kempkes, E. Kremmer, F. W. Pfrieger, L. Espinosa, A. Bigas, C. Giachino, V. Taylor, J. Frisen, D. C. Lie, RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus The Journal of Neuroscience. ,vol. 30, pp. 13794- 13807 ,(2010) , 10.1523/JNEUROSCI.1567-10.2010