Purification and Characterization of Scorpion Toxins Acting on Voltage-Sensitive Na + Channels

作者: Marie-France Martin-Eauclaire , Hervé Rochat

DOI: 10.1007/978-3-0348-8466-2_10

关键词: Sodium channelScorpionBiochemistryIonic ChannelsInsect toxinPeptideScorpion toxinChemistry

摘要: Scorpions produce some of the most potent venoms in animal kingdom. The toxicity these is due to their high content peptide neurotoxins, which are highly active against ionic channels (Miranda et al., 1970). use this cocktail toxins immobilize prey and protect themselves. Their therefore composed a complex mixture polypeptides with different pharmacological activities.

参考文章(100)
P Lazarovici, P Yanai, M Pelhate, E Zlotkin, Insect toxic component from the venom of a chactoid scorpion, Scorpio maurus palmatus (Scorpionidae). Journal of Biological Chemistry. ,vol. 257, pp. 8397- 8404 ,(1982) , 10.1016/S0021-9258(18)34345-X
Francois Miranda, Charles Kupeyan, Herve Rochat, Catherine Rochat, Serge Lissitzky, Purification of Animal Neurotoxins FEBS Journal. ,vol. 16, pp. 514- 523 ,(1970) , 10.1111/J.1432-1033.1970.TB01111.X
Jacques Barhanin, JR Giglio, Pierre Leopold, Annie Schmid, SV Sampaio, M Lazdunski, None, Tityus serrulatus venom contains two classes of toxins. Tityus gamma toxin is a new tool with a very high affinity for studying the Na+ channel. Journal of Biological Chemistry. ,vol. 257, pp. 12553- 12558 ,(1982) , 10.1016/S0021-9258(18)33546-4
E Jover, A Massacrier, P Cau, M F Martin, F Couraud, The correlation between Na+ channel subunits and scorpion toxin-binding sites. A study in rat brain synaptosomes and in brain neurons developing in vitro. Journal of Biological Chemistry. ,vol. 263, pp. 1542- 1548 ,(1988) , 10.1016/S0021-9258(19)57338-0
P E Bougis, H Rochat, L A Smith, Precursors of Androctonus australis scorpion neurotoxins Journal of Biological Chemistry. ,vol. 264, pp. 19259- 19265 ,(1989) , 10.1016/S0021-9258(19)47295-5
J Barhanin, A Schmid, A Lombet, K P Wheeler, M Lazdunski, J C Ellory, Molecular size of different neurotoxin receptors on the voltage-sensitive Na+ channel. Journal of Biological Chemistry. ,vol. 258, pp. 700- 702 ,(1983) , 10.1016/S0021-9258(18)33101-6
L D Possani, B M Martin, M D Fletcher, P L Fletcher, Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom. Journal of Biological Chemistry. ,vol. 266, pp. 3178- 3185 ,(1991) , 10.1016/S0021-9258(18)49971-1
L D Possani, B M Martin, I Svendsen, G S Rode, B W Erickson, Scorpion toxins from Centruroides noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis Biochemical Journal. ,vol. 229, pp. 739- 750 ,(1985) , 10.1042/BJ2290739