Caspase-1-mediated cytokine release from gestational tissues, placental, and cord blood.

摘要: Distinguishing between fetal and maternal inflammatory responses is necessary for understanding the immune interplay either side of placenta. Fetal immunity reaches maturity during extrauterine life while basic afford a certain degree protection in utero fetuses are vulnerable to infection. With discovery inflammasomes – intracellular scaffolds that facilitate elaboration reactions resulting release mature interleukin-1 IL-1 - it consider how stimuli processed. The purinergic P2X7 receptor located on haematopoietic cells key intermediary signal transduction initiated at Toll-like receptors (TLR) terminating IL-1 product. We demonstrate herein from membranes mononuclear isolated cord, placental blood, obtained term, P2X7- caspase-1 dependent. P2X7-dependent cytokine, which was highest choriodecidua, attenuated by progesterone (P4), prolactin an NFkB inhibitor. NLRP3 inflammasome appears processing gestational tissues leukocytes.