Spectrum of Pheochromocytoma in Multiple Endocrine Neoplasia

摘要: Six patients with multiple endocrine neoplasia (MEN) types 2a and 2b were investigated to determine the spectrum of pheochromocytoma by scintigraphy. Iodine-131-metaiodobenzylguanidine (/sup 131/I-MIBG), a new imaging agent which concentrates in adrenergic neurotransmitter vesicles, was administered at 0.5 mCi/1.7m2 scintiscans taken 24 48 hours. Two normotensive normal plasma urinary catecholamines had no adrenal tracer uptake. One patient modest intermittent increase only catecholamine metabolites showed faint images. other increased bilateral patterns. The sixth who norepinephrine epinephrine secretion asymmetrical images, findings that corroborated operation. Functional as well anatomic evidence medullary abnormalities MEN-2 syndromes are demonstrated /sup 131/I-MIBG Therefore, procedure can be used define extent medulla these patients.