Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems.
作者： L J Rasmussen-Torvik , S C Stallings , A S Gordon , B Almoguera , M A Basford
关键词: Medicine 、 Gerontology 、 Process (engineering) 、 Process management 、 Project implementation 、 Sequence variation 、 General partnership 、 Unknown Significance 、 Electronic health record 、 Pharmacogenomics 、 Clinical decision support system
摘要: We describe here the design and initial implementation of eMERGE-PGx project. eMERGE-PGx, a partnership eMERGE PGRN consortia, has three objectives : 1) Deploy PGRNseq, next-generation sequencing platform assessing sequence variation in 84 proposed pharmacogenes, nearly 9,000 patients likely to be prescribed drugs interest 1–3 year timeframe across several clinical sites; 2) Integrate well-established clinically-validated pharmacogenetic genotypes into electronic health record with associated decision support assess process outcomes implementation; 3) Develop repository variants unknown significance linked EHR-based phenotype data for ongoing pharmacogenomics discovery. site-specific project anticipated products, including genetic variant repositories, novel association studies, modules, outcomes, approaches manage incidental findings, patient clinician education methods.
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