Human DNA repair diseases: From genome instability to cancer
作者： Carlos R. Machado , Carlos F.M. Menck
DOI: 10.1590/S0100-84551997000400032
关键词: Cancer 、 Genetics 、 Genetic syndromes 、 DNA repair 、 Genome 、 Xeroderma pigmentosum 、 Biology 、 Genome instability 、 Acquired diseases 、 Human dna
摘要: Several human genetic syndromes have long been recognized to be defective in DNA repair mechanisms. This was first discovered by Cleaver (1968), who showed that cells from patients with xeroderma pigmentosum (XP) were for the ability remove ultraviolet (UV)-induced lesions their genome. Since then, new discoveries promoted studies one of most exciting areas molecular biology. The present work intends give a brief summary main known diseases related and how they may linked acquired such as cancer
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