Autophagy in breast cancer and its implications for therapy.
作者： Alakananda Basu , Savitha Sridharan , Krishna S Paranandi , Kirti Jain
DOI:
关键词: Cancer research 、 Bioinformatics 、 Cancer 、 Metastasis 、 Tumor microenvironment 、 Tumor progression 、 Breast cancer 、 BECN1 、 Programmed cell death 、 Autophagy 、 Medicine
摘要: Autophagy is an evolutionarily conserved process of cellular self-digestion that serves as a mechanism to clear damaged organelles and recycle nutrients. Since autophagy can promote cell survival well death, it has been linked different human pathologies, including cancer. Although mono-allelic deletion autophagy-related gene BECN1 in breast tumors originally indicated tumor suppressive role for cancer, the intense research during last decade suggests progression. It now recognized cells often utilize survive various stresses, such oncogene-induced transformation, hypoxia, endoplasmic reticulum (ER) stress extracellular matrix detachment. Induction by may also contribute dormancy resistance anticancer therapies, thus making inhibitors promising drug candidates cancer treatment. The scientific endeavors continue define precise In this article, we review current literature on development progression discuss potential modulators
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