Excitotoxicity and Neuropsychiatric Disorders
作者： J. W. Olney
DOI: 10.1007/978-3-642-84526-0_8
关键词: Glutamate receptor 、 NMDA receptor 、 Excitatory postsynaptic potential 、 Excitotoxicity 、 Neuroscience 、 Biology 、 Quinolinic acid 、 Receptor 、 Amino acid 、 Central nervous system
摘要: Three decades ago, Curtis and Watkins (1963), using newly developed micro-electrophoretic techniques to examine the membrane-depolarizing properties of glutamate (Glu) related compounds, characterized structural requirements for molecular interaction with an apparent excitatory amino acid (EAA) receptor. However, myriad metabolic involvements Glu, its ability excite neurons throughout central nervous system (CNS) lack any known mechanism terminating action led neuroscientists 1960s 1970s reject Glu as a transmitter candidate. This view has yielded slowly evidence that satisfies criteria today this common acidic is widely accepted front-running candidate at majority synapses in mammalian CNS.
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