Long-term Prognosis of Patients Treated With Radioactive Iodine for Hyperthyroidism

摘要: Radioactive iodine (RAI) has been commonly used to treat hyperthyroidism since the 1940’s. Hypothyroidism become an accepted outcome of RAI treatment. Most clinics therefore prefer a fixed dose regimen in treatment instead calculating on grounds size thyroid gland and uptake RAI. However, no consensus exists regarding ideal first hyperthyroidism. In previous long-term follow-up studies, cardiovascular morbidity mortality have remained increased years after it is not known, which diseases cause risk death. Previous studies cancer patients treated with for conflicting, reporting either increased, decreased or equal RAI-treated compared general population. Moreover, whether etiology hyperthyroidism, RAI, effectiveness contribute mortality. The aim this thesis was clarify these aspects concerning safety Details treatments, 2793 therapy at Tampere University Hospital between 1965 2002 were entered into computerized register. After treatment, status monitored every 1-3 months during year, subsequently years’ intervals until June patient died moved out district. studied 2043 followed-up more than one year (I). cumulative incidence hypothyroidism Graves’ disease 24% 82% 25 years, respectively. developed 4% toxic nodular by 32% Administration single resulted control 75% both etiologic groups. A population-based cohort study conducted among all hyperthyroid 2002, ageand gender-matched reference subjects. period started end subject same time as that corresponding patient. For controls, ended date hospitalization (II), diagnosis (III), death (II-IV), emigration from Finland common closing (December 31, 2003), whichever occurred first. Median 9 years. Information hospitalizations obtained Discharge Registry (HILMO) Finnish Cancer Population Register Centre Statistics (II-IV). rate due higher population (637.1 vs. 476.4 per 10,000 person-years, ratio (RR) 1.12 (95% CI 1.03-1.21), II). elevated up 35 Hospitalizations atrial fibrillation (RR 1.35, 95% 1.11-1.64), cerebrovascular 1.31, 1.14-1.51), other arteries veins 1.22, 1.05-1.43), hypertension 1.20, 1.02-1.41), heart failure 1.48, 1.24-