Chitin Synthase as a Chemotherapeutic Target
作者： N. H. Georgopapadakou
DOI: 10.1007/978-1-4615-3274-3_18
关键词: Candida albicans 、 Morphogenesis 、 Chitin synthase 、 Cell shape 、 Biosynthesis 、 Saccharomyces cerevisiae 、 Chemistry 、 Cell division 、 Cell wall 、 Cell biology
摘要: The fungal cell wall is a major and essential structure, entirely lacking in animal cells, thus an attractive chemotherapeutic target. Its biosynthesis central to division morphogenesis. Like its bacterial counterpart, the determines shape, provides rigidity osmotic support, plays important role adherence pathogenicity (73, 86). It may, addition, constitute permeability barrier (113).
springer.com
sci-hub.st 参考文章(117)
C. E. Bulawa, B. C. Osmond, Chitin synthase I and chitin synthase II are not required for chitin synthesis in vivo in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 7424- 7428 ,(1990) , 10.1073/PNAS.87.19.7424
Ram Minke, John Blackwell, The structure of alpha-chitin. Journal of Molecular Biology. ,vol. 120, pp. 167- 181 ,(1978) , 10.1016/0022-2836(78)90063-3
DONALD R. KIRSCH, MARGARET H. LAI, A modified screen for the detection of cell wall-acting antifungal compounds. The Journal of Antibiotics. ,vol. 39, pp. 1620- 1622 ,(1986) , 10.7164/ANTIBIOTICS.39.1620
J. Au‐Young, P. W. Robbins, Isolation of a chitin synthase gene (CHS1) from Candida albicans by expression in Saccharomyces cerevisiae. Molecular Microbiology. ,vol. 4, pp. 197- 207 ,(1990) , 10.1111/J.1365-2958.1990.TB00587.X
MASAYA HAYASHIBE, SHIGEYOSHI KATOHDA, INITIATION OF BUDDING AND CHITIN-RING Journal of General and Applied Microbiology. ,vol. 19, pp. 23- 39 ,(1973) , 10.2323/JGAM.19.23
C. E. Ballou, S. K. Maitra, J. W. Walker, W. L. Whelan, Developmental defects associated with glucosamine auxotrophy in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 4351- 4355 ,(1977) , 10.1073/PNAS.74.10.4351
Masahiro HORI, Kazuo KAKIKI, Saburo SUZUKI, Tomomasa MISATO, Studies on the Mode of Action of Polyoxins Agricultural and biological chemistry. ,vol. 35, pp. 1280- 1291 ,(1971) , 10.1271/BBB1961.35.1280
Othniel Emter, Dieter H. Wolf, Vacuoles are not the sole compartments of proteolytic enzymes in yeast. FEBS Letters. ,vol. 166, pp. 321- 325 ,(1984) , 10.1016/0014-5793(84)80104-0
G. U. Brillinger, Metabolic products of microorganisms 181. Chitin synthase from fungi, a test model for substances with insecticidal properties Archives of Microbiology. ,vol. 121, pp. 71- 74 ,(1979) , 10.1007/BF00409207
Kiyoshi Isono, Kenichi Asahi, Saburo Suzuki, Studies on polyoxins, antifungal antibiotics. 13. The structure of polyoxins. Journal of the American Chemical Society. ,vol. 91, pp. 7490- 7505 ,(1969) , 10.1021/JA01054A045