Kationentransportstörung an Rh-pos. Erythrozyten nach Inkubation mit IgG-Anti-D
作者： H. Weicker , A. Ruberg , H. Huster
DOI: 10.1016/S0340-904X(77)80057-2
关键词: Intracellular 、 Biochemistry 、 Glycolipid 、 Complement system 、 Lysis 、 Molecular biology 、 Na+/K+-ATPase 、 Cation transport 、 Chemistry 、 Monocyte 、 Hemolysis
摘要: Abstract Rh-pos. human red cells sensitized with IgG-Anti-D showed at 4° C an intracellular Na+-accumulation, which was amplified by increase in the Na+-concentration incubation medium. This of may be due to a passive Na+-influx since Na+-K+-ATPase system does not work this temperature. At optimal reactiontemperature enzyme activity inhibited proportionally anti-D concentration. Both and inhibition active Na+-transport caused osmotic hemolysis. The hemoglobin release significant above titer step 1:512. mechanism suggests that intravasular part immunohemolysis Rh incompatibility generated impaired cation transport following antigen-antibody reaction. suggestion is supported fact neither stimulated complement nor intravascular monocyte mediated cell lysis, effector reduced surplus presence other inhibiting IgG immunoglobulins. biochemical relationship Rh-D-antigen both located on membrane lipoproteins, reason why only antigenantibody reaction Rh-D transport. IgM-Anti-A cold agglutinin IgM-Anti-I reacting glycolipid glycoprotein antigens respectively did impair after inactivation.
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