Sex differences in the timing behavior performance of 3xTg-AD and wild-type mice in the peak interval procedure.

摘要: Abstract We investigated interval timing behavior of 10-month-old male and female 3xTg-AD mice compared with their B6129F2/J wild type controls using the peak procedure a 15 s target interval. Multiple parameters reflecting different aspects performance were extracted from steady-state anticipatory nose-poking two approaches: single trial analyses average response curve analyses. These measures can dissociate differences in due to distortions ability or motivational decline (i.e. apathy); both which have been reported Alzheimer patients. found that did not differ wild-type controls. However, state, we significant sex regardless genotype. Specifically, initiated responding later had lower amplitudes than males. Although our findings also be interpreted terms temporal control for initiation, they more strongly suggest effect differential incentive motivation between sexes on these mice.