Mutations in sfdA and sfdB suppress multiple developmental mutations in Aspergillus nidulans.

摘要: Conidiophore morphogenesis in Aspergillus nidulans occurs response to developmental signals that result the activation of brlA, a well-characterized gene encodes transcription factor is central asexual development. Loss-of-function mutations flbD and other fluffy loci have previously been shown delayed development reduced expression brlA. message detectable during both hyphal growth conidiation, its product similar Myb family factors. To further understand regulatory pathway brlA we isolated suppressor rescued strains with null allele. We describe here two new loci, designated sfdA sfdB for suppressors flbD, bypass requirement sfd mutant alleles were found restore timing deletions. In addition, suppress defects harboring loss-of-function fluG, flbA, flbB, flbC, flbE. All are recessive their wild-type diploids. Strains otherwise developmentally backgrounds phenotypes develop conidiophores submerged cultures.