Advances in Pretransplant Donor-Specific Antibody Testing in Solid Organ Transplantation: From Bench to Bedside

作者: Daniele Focosi

DOI: 10.3109/08830185.2016.1154051

关键词: Bench to bedsideTransplantationImmunologyIntensive care medicineOrgan transplantationSolid organ transplantationRisk stratificationDonor specific antibodiesHuman leukocyte antigenMedicine

摘要: Immunological risk stratification has a central role in determining both the feasibility of solid organ transplantation and type (and amount) induction maintenance immunosuppressive therapy. Currently there is poor consensus on how to exactly estimate global immunological risk, most transplant centers adopt complicated internal guidelines for stratification. Here we systematically review published evidences that should drive appropriateness stratification, focusing donor-specific antibodies against HLA other antigens.

参考文章(137)
Robert Liwski, Sandra Lee, Roxanne Sperry, Peter Nickerson, Robert Bray, Howard Gebel, 60-OR: THE ANTI-HUMAN GLOBULIN ENHANCED C1QSCREEN™ ASSAY IMPROVES THE DETECTION OF COMPLEMENT BINDING DONOR SPECIFIC HLA ANTIBODIES Human Immunology. ,vol. 74, pp. 48- ,(2013) , 10.1016/J.HUMIMM.2013.08.071
Robert Liwski, Sandra Lee, Roxanne Sperry, Anne Halpin, Luis Hidalgo, Patricia Campbell, 61-OR: ANTI-HUMAN GLOBULIN ENHANCED C1qSCREEN™ ASSAY POSITIVITY CORRELATES WITH THE CDC-AHG CROSSMATCH RESULTS Human Immunology. ,vol. 74, pp. 48- ,(2013) , 10.1016/J.HUMIMM.2013.08.072
N Veillard, F Mach, F Mulhaupt, G Pelli, B Kwak, The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells. Swiss Medical Weekly. ,vol. 131, pp. 41- 46 ,(2001) , 10.4414/SMW.2001.06144
Joseph Pilewski, Jon Lomago, John McDyer, John Lunz, Lawrence Jelinek, Adriana Zeevi, Kurt Johnson, Christopher Ensor, Donald Foster, Marilyn Marrari, Christian Bermudez, The big picture: A case report of antibody mediated rejection and treatment after lung transplantation illustrating the need to correlate laboratory findings with clinical status. Clinical Transplantation. pp. 399- 405 ,(2013)
Suratt Pm, Lobo Pi, Studies on the autoantibody to lymphocytes in sarcoidosis. Journal of clinical & laboratory immunology. ,vol. 1, pp. 283- ,(1979)
David Lorentzen, Hans Sollinger, Arjang Djamali, Jose Torrealba, Joshua Mezrich, Erik Schadde, John Pirsch, Mareena Zachariah, Milagros Samaniego, C4d-positive acute antibody-mediated rejection due to anti-HLA-DP antibody: a tale of one patient and a review of the University of Wisconsin experience. Clinical Transplantation. pp. 503- 507 ,(2006)
Katalin Kiss, Judit Cervenak, Ferenc Uher, Partial characterization of two lymphocyte-specific natural autoantibodies isolated from newborn mice. Acta Microbiologica Et Immunologica Hungarica. ,vol. 46, pp. 53- 62 ,(1999)
C. Wiebe, I. W. Gibson, T. D. Blydt-Hansen, M. Karpinski, J. Ho, L. J. Storsley, A. Goldberg, P. E. Birk, D. N. Rush, P. W. Nickerson, Evolution and Clinical Pathologic Correlations of De Novo Donor‐Specific HLA Antibody Post Kidney Transplant American Journal of Transplantation. ,vol. 12, pp. 1157- 1167 ,(2012) , 10.1111/J.1600-6143.2012.04013.X