Oral Versus Intravenous Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients on Maintenance Hemodialysis—Effect on Fibroblast Growth Factor-23 Metabolism
作者： Wataru Fukao , Yukiko Hasuike , Tomo Yamakawa , Kazuhiro Toyoda , Makoto Aichi
DOI: 10.1053/J.JRN.2017.12.009
关键词: Ferritin 、 Ferrous citrate 、 Medicine 、 Anemia 、 Fibroblast growth factor 23 、 Erythropoiesis 、 Internal medicine 、 Mean corpuscular volume 、 Gastroenterology 、 Transferrin saturation 、 Iron-deficiency anemia
摘要: Objective Iron administration affects serum levels of intact (I-) fibroblast growth factor-23 (FGF23) and its cleavage product C-terminal (C-) FGF23 in iron-deficient patients on maintenance hemodialysis (MHD). The objective this study was to compare the effect oral or intravenous iron I-FGF23 C-FGF23 MHD. Design Methods A prospective randomized study. Subjects Participants MHD with severe deficiency (n = 61). Intervention were receive (50 mg sodium ferrous citrate daily; group, n = 29) (40 mg saccharated ferric oxide weekly; IV n = 32). Main Outcome Measure Changes after 10 weeks treatment. Results supplementation significantly increased hemoglobin, mean corpuscular volume, ferritin, transferrin saturation rate, decreased erythropoiesis-stimulating agent dose resistance index value. Serum phosphate, calcium, parathyroid hormone did not change during group whereas reduced both groups. interleukin-6 tumor necrosis factor-α Multiple regression analysis indicated relationship between erythropoiesis metabolism. Conclusion levels, though not. If target chronic kidney disease-mineral bone disorder therapy is reducing we suggest use iron.
jrnjournal.org参考文章(30)
Masafumi Fukagawa, Keitaro Yokoyama, Fumihiko Koiwa, Masatomo Taniguchi, Tetsuo Shoji, Junichiro James Kazama, Hirotaka Komaba, Ryoichi Ando, Takatoshi Kakuta, Hideki Fujii, Msasaaki Nakayama, Yugo Shibagaki, Seiji Fukumoto, Naohiko Fujii, Motoshi Hattori, Akira Ashida, Kunitoshi Iseki, Takashi Shigematsu, Yusuke Tsukamoto, Yoshiharu Tsubakihara, Tadashi Tomo, Hideki Hirakata, Tadao Akizawa, , , Clinical Practice Guideline for the Management of Chronic Kidney Disease‐Mineral and Bone Disorder Therapeutic Apheresis and Dialysis. ,vol. 17, pp. 247- 288 ,(2013) , 10.1111/1744-9987.12058
Myles Wolf, Todd A Koch, David B Bregman, Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women. Journal of Bone and Mineral Research. ,vol. 28, pp. 1793- 1803 ,(2013) , 10.1002/JBMR.1923
Akira Iguchi, Junichiro J. Kazama, Suguru Yamamoto, Kazuhiro Yoshita, Yasuo Watanabe, Noriaki Iino, Ichiei Narita, Administration of Ferric Citrate Hydrate Decreases Circulating FGF23 Levels Independently of Serum Phosphate Levels in Hemodialysis Patients with Iron Deficiency. Nephron. ,vol. 131, pp. 161- 166 ,(2015) , 10.1159/000440968
Alexander Grabner, Ansel P Amaral, Karla Schramm, Saurav Singh, Alexis Sloan, Christopher Yanucil, Jihe Li, Lina A Shehadeh, Joshua M Hare, Valentin David, Aline Martin, Alessia Fornoni, Giovana Seno Di Marco, Dominik Kentrup, Stefan Reuter, Anna B Mayer, Hermann Pavenstädt, Jörg Stypmann, Christian Kuhn, Susanne Hille, Norbert Frey, Maren Leifheit-Nestler, Beatrice Richter, Dieter Haffner, Reimar Abraham, Johannes Bange, Bianca Sperl, Axel Ullrich, Marcus Brand, Myles Wolf, Christian Faul, Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy Cell Metabolism. ,vol. 22, pp. 1020- 1032 ,(2015) , 10.1016/J.CMET.2015.09.002
Valentin David, Aline Martin, Tamara Isakova, Christina Spaulding, Lixin Qi, Veronica Ramirez, Kimberly B. Zumbrennen-Bullough, Chia Chi Sun, Herbert Y. Lin, Jodie L. Babitt, Myles Wolf, Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production Kidney International. ,vol. 89, pp. 135- 146 ,(2016) , 10.1038/KI.2015.290
JUNPING LI, YANLI HOU, SHUPING ZHANG, HONG JI, HAIQIN RONG, GUANGBO QU, SIJIN LIU, Excess iron undermined bone load-bearing capacity through tumor necrosis factor-α-dependent osteoclastic activation in mice. Biomedical Reports. ,vol. 1, pp. 85- 88 ,(2013) , 10.3892/BR.2012.6
Orlando M. Gutiérrez, Michael Mannstadt, Tamara Isakova, Jose Alejandro Rauh-Hain, Hector Tamez, Anand Shah, Kelsey Smith, Hang Lee, Ravi Thadhani, Harald Jüppner, Myles Wolf, Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. The New England Journal of Medicine. ,vol. 359, pp. 584- 592 ,(2008) , 10.1056/NEJMOA0706130
Soheir Beshara, Jens Sörensen, Mark Lubberink, Vladimir Tolmachev, Bengt Långström, Gunnar Antoni, Bo G. Danielson, Hans Lundqvist, Pharmacokinetics and red cell utilization of 52
Fe/59
Fe-labelled iron polymaltose in anaemic patients using positron emission tomography British Journal of Haematology. ,vol. 120, pp. 853- 859 ,(2003) , 10.1046/J.1365-2141.2003.03590.X
Günter Weiss, Edgar Meusburger, Gudrun Radacher, Katja Garimorth, Ulrich Neyer, Gert Mayer, None, Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietin Kidney International. ,vol. 64, pp. 572- 578 ,(2003) , 10.1046/J.1523-1755.2003.00099.X
Christian Faul, Ansel P. Amaral, Behzad Oskouei, Ming-Chang Hu, Alexis Sloan, Tamara Isakova, Orlando M. Gutiérrez, Robier Aguillon-Prada, Joy Lincoln, Joshua M. Hare, Peter Mundel, Azorides Morales, Julia Scialla, Michael Fischer, Elsayed Z. Soliman, Jing Chen, Alan S. Go, Sylvia E. Rosas, Lisa Nessel, Raymond R. Townsend, Harold I. Feldman, Martin St. John Sutton, Akinlolu Ojo, Crystal Gadegbeku, Giovana Seno Di Marco, Stefan Reuter, Dominik Kentrup, Klaus Tiemann, Marcus Brand, Joseph A. Hill, Orson W. Moe, Makoto Kuro-o, John W. Kusek, Martin G. Keane, Myles Wolf, FGF23 induces left ventricular hypertrophy Journal of Clinical Investigation. ,vol. 121, pp. 4393- 4408 ,(2011) , 10.1172/JCI46122