The spectrum of hepatic functional impairment in compensated chronic hepatitis C: results from the Hepatitis C Anti-viral Long-term Treatment against Cirrhosis Trial.

摘要: Summary Background  The spectrum of functional impairment in patients with compensated chronic hepatitis C is incompletely defined. Aim  To define hepatic by quantitative tests (quantitative liver function tests) and correlate results disease severity C. Methods  We studied 285 adult prior to treatment the Hepatitis Anti-viral Long-term Treatment against Cirrhosis Trial; 171 had Ishak fibrosis stages 2–4 (fibrosis) 114 stage 5 or 6 (cirrhosis). None clinical decompensation. A battery 12 test assessed microsomal, mitochondrial cytosolic functions, portal blood flow. Results  Twenty-six 63% 45–89% cirrhosis test; greatest (P-value ranging from 0.15 35% identified 91% medium- large-sized varices. Conclusions  Hepatic common because C. Cholate shunt, cholate Cloral perfused mass, identify at risk for varices.