NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures

作者: Rivka Colen , Ian Foster , Robert Gatenby , Mary Ellen Giger , Robert Gillies

DOI: 10.1016/J.TRANON.2014.07.007

关键词: Cancer biologyRadiogenomicsBiological propertyCancer Imaging ProgramDecision support systemData scienceGenomicsMedicineResearch communityInformatics

摘要: The National Cancer Institute (NCI) Imaging Program organized two related workshops on June 26-27, 2013, entitled "Correlating Phenotypes with Genomics Signatures Research" and "Scalable Computational Resources as Required for Imaging-Genomics Decision Support Systems." first workshop focused clinical scientific requirements, exploring our knowledge of phenotypic characteristics cancer biological properties to determine whether the field is sufficiently advanced correlate imaging phenotypes that underpin genomics outcomes, new methods extract features from medical images relate them analyses. second computational explore informatics requirements analyses improve accessibility speed dissemination existing NIH resources. These linked currently known genotypic biology outcomes. group generated a set recommendations NCI leadership research community encourage support development emerging radiogenomics address short-and longer-term goals in research.

参考文章(56)
Joel H Saltz, Lee A D Cooper, Jun Kong, David A Gutman, Fusheng Wang, Jingjing Gao, Christina Appin, Sharath Cholleti, Tony Pan, Ashish Sharma, Lisa Scarpace, Tom Mikkelsen, Tahsin Kurc, Carlos S Moreno, Daniel J Brat, Integrated morphologic analysis for the identification and characterization of disease subtypes. Journal of the American Medical Informatics Association. ,vol. 19, pp. 317- 323 ,(2012) , 10.1136/AMIAJNL-2011-000700
Stacey E Mills, Darryl Carter, Joel K Greenson, Victor E Reuter, Mark H Stoler, Sternberg's Diagnostic Surgical Pathology ,(2012)
Jon C. Aster, Abul K. Abbas, Vinay Kumar, James A. Perkins, Robbins & Cotran Pathologic Basis of Disease ,(2004)
Elizabeth M. C. Hillman, Anna Moore, All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast. Nature Photonics. ,vol. 1, pp. 526- 530 ,(2007) , 10.1038/NPHOTON.2007.146
Steven C. Sauk, Margaret S. Hsu, Daniel J. A. Margolis, David S. K. Lu, Nagesh P. Rao, Arie S. Belldegrun, Allan J. Pantuck, Steven S. Raman, Clear Cell Renal Cell Carcinoma: Multiphasic Multidetector CT Imaging Features Help Predict Genetic Karyotypes Radiology. ,vol. 261, pp. 854- 862 ,(2011) , 10.1148/RADIOL.11101508
Lori A Erickson, Sternberg??s Diagnostic Surgical Pathology, 4th ed The American Journal of Surgical Pathology. ,vol. 29, pp. 425- ,(2005) , 10.1097/01.PAS.0000153467.14045.77
Tahsin Kurc, Ashish Sharma, TaeW Oh, AltonB Farris, Joel Saltz, Fusheng Wang, Lee Cooper, Jun Kong, Tony Pan, Wenjin Chen, Cristobal Niedermayr, Daniel Brat, DavidJ Foran, A data model and database for high-resolution pathology analytical image informatics. Journal of Pathology Informatics. ,vol. 2, pp. 32- 32 ,(2011) , 10.4103/2153-3539.83192
Rodney H. Reznek, CT/MRI in staging renal cell carcinoma. Cancer Imaging. ,vol. 4, ,(2004) , 10.1102/1470-7330.2004.0012
Sohrab P Shah, Ryan D Morin, Jaswinder Khattra, Leah Prentice, Trevor Pugh, Angela Burleigh, Allen Delaney, Karen Gelmon, Ryan Guliany, Janine Senz, Christian Steidl, Robert A Holt, Steven Jones, Mark Sun, Gillian Leung, Richard Moore, Tesa Severson, Greg A Taylor, Andrew E Teschendorff, Kane Tse, Gulisa Turashvili, Richard Varhol, René L Warren, Peter Watson, Yongjun Zhao, Carlos Caldas, David Huntsman, Martin Hirst, Marco A Marra, Samuel Aparicio, None, Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution Nature. ,vol. 461, pp. 809- 813 ,(2009) , 10.1038/NATURE08489
Maryellen L Giger, Update on the potential of computer-aided diagnosis for breast cancer Future Oncology. ,vol. 6, pp. 1- 4 ,(2010) , 10.2217/FON.09.154