Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

摘要: Delta and mu opioid receptors (DORs MORs) are inhibitory G protein-coupled that reportedly cooperatively regulate the transmission of pain messages by substance P TRPV1-expressing fibers. Using a DOReGFP reporter mouse we now show DOR MOR are, in fact, expressed different subsets primary afferents. The is peptidergic fibers, myelinated nonpeptidergic Contrary to prevailing view, demonstrate trafficked cell surface under resting conditions, independently P, internalized following activation agonists. Finally, segregated distribution paralleled remarkably selective functional contribution two control mechanical heat pain, respectively. These results behaviorally relevant modalities can be selectively regulated through targeting distinct afferent