Combination of fused deposition modeling and gas foaming technique to fabricated hierarchical macro/microporous polymer scaffolds
作者： Changchun Zhou , Ke Yang , Kefeng Wang , Xuan Pei , Zhihong Dong
DOI: 10.1016/J.MATDES.2016.07.094
关键词: Materials science 、 Science, technology and society 、 Fused deposition modeling 、 Polylactic acid 、 Scaffold 、 Porosity 、 3D printing 、 Fabrication 、 Microporous material 、 Nanotechnology
摘要: Abstract The design and fabrication of porous scaffold remains a major challenge in bone tissue engineering. Hierarchical microporous macroporous structures contribute different biological functions to regeneration. This study introduced an integrated manufacturing method fabricate hierarchical polymer scaffolds. Firstly, polylactic acid (PLA) scaffolds with 100–800 μm macropores were fabricated by applying fused deposition modeling (FDM) techniques. Then, 1–10 μm micropores generated through gas foaming. combined technique avoids the disadvantages pure 3DP or foaming technology elicits positive cooperative effects porosity could offer innovative opportunities control cell performance within 3D microenvironments.
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