Dantrolene sodium reverses the increase in cAMP response element and TPA responsive element DNA-binding activity in the rabbit brain following haloperidol administration and heat stress
作者： HISASHI TANII , NORIO TANIGUCHI , ICHIRO TSUJIO , MASATO ASANUMA , EMI IWATA
DOI: 10.1111/J.1440-1819.1997.TB02610.X
关键词: Striatum 、 Response element 、 Mechanism of action 、 Dantrolene 、 Hypothalamus 、 Internal medicine 、 Endocrinology 、 Haloperidol 、 Dantrolene Sodium 、 Central nervous system 、 Chemistry
摘要: Using electrophoretic mobility-shift assay (EMSA), we examined DNA-binding activity of cAMP response element (CRE), onto its responsive CRE, as well TPA (TRE) in the medial hypothalamus and striatum experimental rabbits administered with haloperidol under heat stress exposure studied effects dantrolene sodium to transcriptional factor. In EMSA nuclear extracts from rabbit brain, activities CRE TRE increased following stress. These increases were maintained by coadministration atropine. The treatment markedly reversed such increases. alterations these factors may reflect therapeutic effect sodium.
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