Anatomy and Function of the Classic Vasopressin-Secreting Hypothalamus-Neurohypophysial System
作者： J. F. Morris , D. B. Chapman , H. W. Sokol
DOI: 10.1007/978-1-4615-8129-1_1
关键词: Neurosecretion 、 Hypothalamus 、 Biology 、 Supraoptic nucleus 、 Magnocellular cell 、 Oxytocin 、 Central nervous system 、 Anatomy 、 Brattleboro rat 、 Vasopressin
摘要: It is probably no exaggeration to declare that the hypothalamus-neurohypophysial system (HNS) quintessence of neurosecretion and vasopressin (VP) quintessential brain peptide. The comprises magnocellular neurons, with cell bodies located in hypothalamus, which project release their hormone neurohypophysis, a large storage organ outside confines central nervous (CNS). Most VP oxytocin (OX) neurons have (25–30-μm diameter) segregated relatively discrete supraoptic nuclei (SON) paraventricular (PVN) hypothalamus (Fig. 1). Since released into systemic circulation stimulates distant target organs, it fits definition true hormone, but may effects CNS as well. unique anatomy this not only contributed its early discovery also facilitated subsequent experimental manipulation accessible neurosecretory complex. Also, Brattleboro rat, fails produce hypothalamic homozygous form (see Valtin, 1982) and, much lesser extent, mice hereditary diabetes insipidus resulting from renal unresponsiveness (Falconer et al., 1964), has provided animal models great value.
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