Toward a comprehensive assessment of functional outcomes in pediatric patients with brain arteriovenous malformations: the Pediatric Quality of Life Inventory.

摘要: OBJECTIVE Brain arteriovenous malformations (bAVMs) are rare in pediatric patients but represent the most common cause of hemorrhagic stroke this population. Pediatric demonstrate superior outcomes comparison with adult similar lesions and presentations. Most studies clinical bAVMs use modified Rankin Scale (mRS), despite a lack validation patients. METHODS The authors interviewed parents 26 who underwent multimodality bAVM treatment administered Quality Life Inventory (PedsQL)-a well-validated tool for that quantifies performance physical, emotional, social, school domains. They also reviewed information from patients' medical charts. Statistical analysis was performed using log-transformed t-test, Mann-Whitney exact test, Kruskal-Wallis Spearman correlation. In addition, literature prior reports outcome cases bAVM. RESULTS average PedsQL health-related quality life score 71 ± 24, an age at diagnosis 12.5 years follow-up period 6.8 years. Seventeen (65%) presented hemorrhage 4 (15%) seizures. scores correlated strongly statistically significant level (p < 0.001) mRS, Overall Performance Category (POPC), Cerebral (PCPC), Glasgow Outcome scores. Multivariate modeling validated special education, corrective devices, cure status as predictors Statistically risk factors undergoing placement ventriculoperitoneal shunt included lower Coma motor on admission = 0.042), cerebellar location 0.046), nidus volume 0.017). Neither modality nor affected follow-up. CONCLUSIONS There have been few long-term patients, previously published used conventional metrics population, such mRS. Although these can serve reasonable surrogates, accurate understanding overall is contingent utilizing toolsets, PedsQL.