Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child.

作者: James N. Martin , Carl H. Rose , Christian M. Briery

DOI: 10.1016/J.AJOG.2005.08.044

关键词: Intensive care medicineEclampsiaPregnancyPreeclampsiaMaternal morbidityDisease PresentationMedicineHELLP syndromePatient experienceObstetricsSevere preeclampsia

摘要: Antepartum or postpartum HELLP syndrome constitutes an obstetric emergency that requires expert knowledge and management skills. The insidious variable nature of disease presentation progression challenges the clinician complicates consensus on universally accepted diagnostic classification criteria. A critical review published research about this variant form severe preeclampsia, focused primarily what is known pathogenesis disorder as it relates to patient experience with corticosteroids for its management, leads conclusion there maternal-fetal benefit realized when potent glucocorticoids are aggressively used treatment. Although acknowledging need definitive multicenter trials better define limits presence any maternal fetal risk, given understanding potential cause considerable morbidity mortality, we recommend present constitute cornerstone patients considered have syndrome.

参考文章(228)
Joan M.G. Crane, Baharak Tabarsi, Donna Hutchens, The Maternal Benefits of Corticosteroids with HELLP (Hemolysis, Elevated Liver Enzymes, Low Platelet Count) Syndrome Journal of obstetrics and gynaecology Canada. ,vol. 25, pp. 650- 655 ,(2003) , 10.1016/S1701-2163(16)30123-2
Frank Lombano, Barry S. Block, Michael Lilly, Yvonne G. Gollin, Melissa Y. Kidder, Recurrence of microangiopathic hemolytic anemia after apparent recovery from the HELLP syndrome. A case report. Journal of Reproductive Medicine. ,vol. 47, pp. 875- 877 ,(2002)
Faridi A, Rath W, Differential HELLP syndrome diagnosis Zeitschrift Fur Geburtshilfe Und Neonatologie. ,vol. 200, pp. 88- 95 ,(1996)
V. Guillaume, J. Horovitz, J.-P. Estrade, E. Roussillon, D. Ekouevi, F. Guyon, [Importance of thrombocytopenia for the management of HELLP syndrome: a report of 104 cases]. Journal De Gynecologie Obstetrique Et Biologie De La Reproduction. ,vol. 32, pp. 541- 548 ,(2003)
Thomas J. Garite, Thomas H. Strong, Michael R. Foley, Obstetric Intensive Care Manual ,(2004)
Everett F. Magann, Kenneth G. Perry, Suneet P. Chauhan, Glen R. Graves, Pamela G. Blake, James N. Martin, Neonatal Salvage by Weeks' Gestation in Pregnancies Complicated by HELLP Syndrome Journal of The Society for Gynecologic Investigation. ,vol. 1, pp. 206- 209 ,(1994) , 10.1177/107155769400100305
Tiberiu Ezri, Ezzat Abouleish, Charles Lee, Shmuel Evron, Intracranial subdural hematoma following dural puncture in a parturient with HELLP syndrome Canadian Journal of Anaesthesia-journal Canadien D Anesthesie. ,vol. 49, pp. 820- 823 ,(2002) , 10.1007/BF03017415