The use of selective progestin receptor modulators (SPRMs) and more specifically ulipristal acetate in the practice of gynaecology.
作者： Serge Rozenberg , Julie Praet , Eliza Pazzaglia , Christine Gilles , Yannick Manigart
DOI: 10.1111/AJO.12641
关键词: Family planning 、 Emergency contraception 、 Medicine 、 Hormone antagonist 、 Gynecology 、 Progestin 、 Endometriosis 、 Hysterectomy 、 Breast cancer 、 Ulipristal acetate
摘要: This review discusses the development of selective progestin receptor modulators (SPRM) for use in women's health and specifically ulipristal acetate (UPA) as emergency contraception (EC) a treatment symptomatic fibroids women who want to preserve their fertility or avoid hysterectomy. As an EC, UPA 30 mg should be recommended women, within 102 h unprotected intercourse. fibroids, (5 mg daily dose) administered periods three months pre-surgical strategy, reducing bleeding fibroid size facilitating surgery. A proportion these patients may even Future developments will demonstrate whether can used other indications such endometriosis breast cancer prevention treatment.
ulb.ac.be
core.ac.uk 
sci-hub.se 参考文章(41)
Jie Shen, Yan Che, Emily Showell, Ke Chen, Linan Cheng, Interventions for emergency contraception Cochrane Database of Systematic Reviews. ,vol. 8, pp. 0- 0 ,(2017) , 10.1002/14651858.CD001324.PUB5
Jacques Donnez, Olivier Donnez, Dace Matule, Hans-Joachim Ahrendt, Robert Hudecek, Janos Zatik, Zaneta Kasilovskiene, Mihai Cristian Dumitrascu, Hervé Fernandez, David H. Barlow, Philippe Bouchard, Bart C.J.M. Fauser, Elke Bestel, Ernest Loumaye, Long-term medical management of uterine fibroids with ulipristal acetate Fertility and Sterility. ,vol. 105, pp. 165- 173.e4 ,(2016) , 10.1016/J.FERTNSTERT.2015.09.032
Alistair R. W. Williams, Christine Bergeron, David H. Barlow, Alex Ferenczy, Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate International Journal of Gynecological Pathology. ,vol. 31, pp. 556- 569 ,(2012) , 10.1097/PGP.0B013E318251035B
Mohamed F. M. Mitwally, Lynda Gotlieb, Robert F. Casper, Prevention of bone loss and hypoestrogenic symptoms by estrogen and interrupted progestogen add-back in long-term GnRH-agonist down-regulated patients with endometriosis and premenstrual syndrome. Menopause. ,vol. 9, pp. 236- 241 ,(2002) , 10.1097/00042192-200207000-00004
Lucy H.R. Whitaker, Alistair R.W. Williams, Hilary O.D. Critchley, Selective progesterone receptor modulators. Current Opinion in Obstetrics & Gynecology. ,vol. 26, pp. 237- 242 ,(2014) , 10.1097/GCO.0000000000000082
Jacques Donnez, Francisco Vázquez, Janusz Tomaszewski, Kazem Nouri, Philippe Bouchard, Bart C.J.M. Fauser, David H. Barlow, Santiago Palacios, Olivier Donnez, Elke Bestel, Ian Osterloh, Ernest Loumaye, Long-term treatment of uterine fibroids with ulipristal acetate ☆ Fertility and Sterility. ,vol. 101, pp. 1565- 1573 ,(2014) , 10.1016/J.FERTNSTERT.2014.02.008
Christina Wang, Amiya Sinha-Hikim, Andrew Leung, The anti-progestin CDB 2914 has no antifertility effect in male rats Contraception. ,vol. 51, pp. 215- 218 ,(1995) , 10.1016/0010-7824(95)00020-B
Ralph Miech, Immunopharmacology of ulipristal as an emergency contraceptive. International Journal of Women's Health. ,vol. 3, pp. 391- 397 ,(2011) , 10.2147/IJWH.S25887
Oliver Pohl, R. Howard Zobrist, Jean-Pierre Gotteland, The Clinical Pharmacology and Pharmacokinetics of Ulipristal Acetate for the Treatment of Uterine Fibroids Reproductive Sciences. ,vol. 22, pp. 476- 483 ,(2015) , 10.1177/1933719114549850
YongMei Huang, Jeffrey T. Jensen, Vivian Brache, Leila Cochon, Alistair Williams, Maria-José Miranda, Horacio Croxatto, Narender Kumar, Heather Sussman, Elena Hoskin, Marlena Plagianos, Kevin Roberts, Ruth Merkatz, Diana Blithe, Regine Sitruk-Ware, A randomized study on pharmacodynamic effects of vaginal rings delivering the progesterone receptor modulator ulipristal acetate: research for a novel estrogen-free, method of contraception Contraception. ,vol. 90, pp. 565- 574 ,(2014) , 10.1016/J.CONTRACEPTION.2014.08.006