PLACEBO-CONTROLLED TRIAL OF RECOMBINANT α2-INTERFERON IN CHINESE HBsAg-CARRIER CHILDREN
作者： Ching-Lung Lai , Hsiang-Ju Lin , Eng-Kiong Yeoh , Anna Suk-Fong Lok , Pui-Chee Wu
DOI: 10.1016/S0140-6736(87)91371-7
关键词: HBeAg 、 Immunology 、 Viral disease 、 Alpha interferon 、 Interferon alfa 、 Placebo-controlled study 、 Hepatitis B virus DNA polymerase 、 HBsAg 、 Placebo 、 Medicine
摘要: Abstract 24 Chinese children aged 1·5-5 years and positive for hepatitis B surface antigen (HBsAg), e (HBeAg), virus DNA polymerase (HBV DNAp), HBV on at least three occasions in the 6 months before trial were randomised to receive either vitamin complex or intramuscular recombinant α 2 -interferon (r-IFN) ('Roferon') 10 x IU/m thrice weekly 12 weeks. In all subjects receiving r-IFN, DNAp levels fell during course of r-IFN injections. Within 4 weeks cessation injection, returned pre-trial except subjects, whom loss was sustained up 18 from onset trial. 1 child lost HBeAg months. placebo group also had a months, with losing All remained HBsAg. produced very slight side-effects pyrexia "flu" syndrome, both which showed rapid tachyphylaxis. dose given safe but no long-term beneficial effects HBsAg carriage children.
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