Effectiveness of gemcitabine, pegaspargase, cisplatin, and dexamethasone (DDGP) combination chemotherapy in the treatment of relapsed/refractory extranodal NK/T cell lymphoma: a retrospective study of 17 patients.
作者： Zhiyuan Zhou , Xiang Li , Changying Chen , Xin Li , Lei Zhang
DOI: 10.1007/S00277-014-2136-7
关键词: Surgery 、 Pegaspargase 、 Gemcitabine 、 Neutropenia 、 Oncology 、 Ifosfamide 、 Combination chemotherapy 、 Chemotherapy 、 Regimen 、 Etoposide 、 Internal medicine 、 Medicine
摘要: The prognosis of extranodal nature killer (NK)/T cell lymphoma (ENKL) is dismal because its aggressive course and multidrug resistance. Currently, for patients with relapsed/refractory ENKL, L-asparaginase-based regimens such as L-asparaginase, ifosfamide, methotrexate, etoposide, dexamethasone (SMILE) or (AspaMetDex) are recommended. We retrospectively investigated the efficacy safety gemcitabine, pegaspargase, cisplatin, (DDGP) combination chemotherapy in treatment 17 ENKL patients. Clinical data from these were collected analyzed. primary end point was overall response rate (ORR). All subjected to 2 6 cycles DDGP chemotherapy, median number regimen administrated four. ORR 88.2 % (15/17), nine (52.9 %) achieved complete (CR) six (35.3 partial (PR). follow-up time months (range 2-28 months). 1-year survival (OS) progression-free (PFS) 82.4 64.7 %, respectively. For those CR responders, PFS months. Grade 3/4 neutropenia occurred grade thrombocytopenia %). produces favorable outcomes more attention should be paid treatment-related myelosuppression. Further prospective trials expected define efficacy.
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