Production of GPCR and GPCR complexes for structure determination.
作者： Shoji Maeda , Gebhard FX Schertler
DOI: 10.1016/J.SBI.2013.04.006
关键词: Computational biology 、 G protein-coupled receptor 、 Nanotechnology 、 Structure (mathematical logic) 、 Computer science
摘要: Since the first high-resolution structure of beta 2 adrenergic receptor (b2AR) in 2007, we have seen a growing number G-protein-coupled (GPCR) structures coming to repertory, providing significant progress our understanding structural basis their function. This has been achieved by interdisciplinary collaborative work between scientists with various expertise and development new methodologies as well combining optimizing existing techniques.
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