Recommendations for the treatment of factor VIII inhibitors: from the UK Haemophilia Centre Directors' Organisation Inhibitor Working Party.

摘要: A strategy is described for the initial detection, management and elimination of factor VIII inhibitors arising in patients with congenital acquired haemophilia A. It suggested that children severe should be screened every 3 months up to age 10 years using Bethesda method. Factor these abolished immune-tolerance induction wherever possible. Such regimes started as early possible, preferably when inhibitor titre < Units (BU)/ml, not interrupted. High-intensity are recommended whose exceed BU. Autoantibodies giving rise high-dose immunoglobulin or conventional immunosuppression. The choice haemostatic agent treatment bleeding based upon clinical circumstances current value, measured both human porcine assay. past anamnestic response also considered choosing minor episodes.