Delineating common molecular mechanisms in Alzheimer's and prion diseases
作者： Kevin J. Barnham , Roberto Cappai , Konrad Beyreuther , Colin L. Masters , Andrew F. Hill
DOI: 10.1016/J.TIBS.2006.06.006
关键词: Peptide 、 Reactive oxygen species 、 Protein aggregation 、 Pathogenesis 、 Biology 、 Amyloid precursor protein 、 Alzheimer's disease 、 Oxidative stress 、 Protein structure 、 Biochemistry
摘要: The structure of the infectious agent responsible for prion diseases has not been fully characterized, but evidence points to a β-rich conformer host-encoded protein. Amyloid-β peptide (Aβ), proteolytic fragment generated from amyloid precursor protein, implicated as toxic molecule involved in pathogenesis Alzheimer's disease. mechanism Aβ toxicity might be mediated through coordination redox-active transition-metal ions such copper leading generation reactive oxygen species, coupled with propensity interact lipid bilayers. Key sequence and chemical similarities between protein (PrP) indicate that similar therapeutic strategies applicable treatment diseases.
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