Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells
作者： Bing He , Yanyan Chang , Chao Yang , Zhanglin Zhang , Guiping Xu
DOI: 10.1016/J.BBRC.2018.10.125
关键词: Acute promyelocytic leukemia 、 Cancer 、 Gene knockdown 、 In patient 、 ADENYLATE CYCLASE 7 、 Cancer research 、 Intracellular 、 Cellular differentiation 、 Retinoic acid 、 Medicine
摘要: Adenylate cyclase 7 (AC7) has been reported to participate in various biological processes during cancer progression. However, the roles of AC7 all-trans retinoic acid (ATRA)-induced differentiation acute promyelocytic leukemia (APL) cells are still unknown. In this study, firstly, our results showed that affected intracellular cAMP level and influenced ATRA-induced APL cells. Secondly, we revealed miR-192 could directly target expression knockdown promoted cell by regulating expression. Furthermore, found was lower patients with relapsed than newly diagnosed APL, while relatively higher APL. Taken together, show miR-192-mediated play important cells, might be new biomarkers therapeutic targets for
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