Epidermotropic cutaneous T-cell lymphoma (mycosis fungoides) in Syrian hamsters (Mesocricetus auratus). A report of six cases and the demonstration of T-cell specificity

作者: RICHARD G. HARVEY , TREVOR J. WHITBREAD , LUIS FERRER , JOHN E. COOPER

DOI: 10.1111/J.1365-3164.1992.TB00138.X

关键词: GynecologyCutaneous T-cell lymphoma/Mycosis fungoidesPathologySyrian hamstersT-Cell SpecificityExfoliative erythrodermaMycosis fungoidesMesocricetusMedicine

摘要: — Epidermotropic cutaneous T-cell lymphoma was diagnosed in six Syrian hamsters (Mesocricetus auratus) with a generalised dermatosis characterised by pruritus, alopecia and exfoliative erythroderma. Plaques nodules were evident one animal. Clinical histopathological findings suggestive of mycosis fungoides electron microscopical investigations case supportive. Immuno-histochemical stains for CD3 antigen strongly positive all cases. Resume— Un lyphome T cutane ete diagnostique chez de Siberie avec une dermatose generalisee, caracterisee par un prurit, alopecle et erythrodermie exfoliative. Des plaques des ont observees sur Les donnees cliniques histopathologiques etaient evocatrices d'un les examens en microscopie electronique compatibles dans cas. marquages immuno-histochimiques l'antigene tres positifs tous cas. Zusammenfassung— Bei sechs Syrischen Goldhamstern wurde ein epidermotropes kutanes T-Zell-Lymphom mit einer generalisierten Dermatose diagnostiziert, die durch Pruritus, Alopezie und eine Erythrodermie gekennzeichnet war. einem Tier traten auch Plagues Knoten auf. Die klinischen histopathologischen Befunde deuteten auf Mycosis hin. Elektronenmikroskopische Untersuchungen unterstutzten diesen Verdacht Fall. Immunhistochemische Farbungen CD3-Antigen waren bei alien Fallen stark positiv. Resumen  En grupo seis siria, auratus), se diagnostico limfoma epidermotropico cutaneo linfocitos T, presentando una generalizada tipo pruriginoso, acompanada y eritroderma exfoliativo. Las placas nodulos fueron evidentes uno los animales. Los estudios clinicos e histopatologicos indicaron micosis fungoide, las investigaciones microscopia, caseos, parecio indicar lo mismo. La tintura inmuno-histoquimica para el antigeno resulto claramente positiva todod casos.

参考文章(22)
P. F. Moore, J. M. Turrel, D. J. DeBoer, Mycosis fungoides in a dog: demonstration of T-cell specificity and response to radiotherapy. Journal of The American Animal Hospital Association. ,vol. 26, pp. 566- 572 ,(1990)
R. D. Zwahlen, A. Tontis, A. Schneider, Cutaneous lymphosarcoma of helper/inducer T-cell origin in a calf Veterinary Pathology. ,vol. 24, pp. 504- 508 ,(1987) , 10.1177/030098588702400606
D Y Mason, J Cordell, M Brown, G Pallesen, E Ralfkiaer, J Rothbard, M Crumpton, K C Gatter, Detection of T cells in paraffin wax embedded tissue using antibodies against a peptide sequence from the CD3 antigen. Journal of Clinical Pathology. ,vol. 42, pp. 1194- 1200 ,(1989) , 10.1136/JCP.42.11.1194
Mark A. Goldsmith, Arthur Weiss, New clues about T-cell antigen receptor complex function Immunology Today. ,vol. 9, pp. 220- 222 ,(1988) , 10.1016/0167-5699(88)91219-4
D. F. KELLY, R. E. W. HALLIWELL, R. M. SCHWARTZMAN, Generalized cutaneous eruption in a dog, with histological similarity to human mycosis fungoides. British Journal of Dermatology. ,vol. 86, pp. 164- 171 ,(1972) , 10.1111/J.1365-2133.1972.TB16081.X
C. J. L. M. Meijer, E. M. van der Loo, W. A. van Vloten, E. A. van der Velde, E. Scheffer, C. J. Cornelisse, Early diagnosis of mycosis fungoides and Sézary's syndrome by morphometric analysis of lymphoid cells in the skin Cancer. ,vol. 45, pp. 2864- 2871 ,(1980) , 10.1002/1097-0142(19800601)45:11<2864::AID-CNCR2820451124>3.0.CO;2-Z
SCOTT C. DUNCAN, R. K. WINKELMANN, Circulating Sézary cells in hospitalized dermatology patients British Journal of Dermatology. ,vol. 99, pp. 171- 178 ,(1978) , 10.1111/J.1365-2133.1978.TB01978.X
N Hastrup, E Ralfkiaer, G Pallesen, Aberrant phenotypes in peripheral T cell lymphomas. Journal of Clinical Pathology. ,vol. 42, pp. 398- 402 ,(1989) , 10.1136/JCP.42.4.398
B. L. Mepham, W. Frater, B. S. Mitchell, The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique. Histochemical Journal. ,vol. 11, pp. 345- 357 ,(1979) , 10.1007/BF01005033
D Y Mason, G W Krissansen, F R Davey, M J Crumpton, K C Gatter, Antisera against epitopes resistant to denaturation on T3 (CD3) antigen can detect reactive and neoplastic T cells in paraffin embedded tissue biopsy specimens Journal of Clinical Pathology. ,vol. 41, pp. 121- 127 ,(1988) , 10.1136/JCP.41.2.121