Development and Validation of a Kinematically-Driven Computational Model of the Patellofemoral Joint

摘要: The patellofemoral joint represents one of the most challenging musculoskeletal systems to understand and manage. Disruption in normal tracking can lead elevated stress microtrauma articular cartilage, cascading development osteoarthritis. To develop effective treatment therapies, relationships between altered patellar motion subsequent changes cartilage loading must be measured. Computational modeling provides joint-specific contact mechanics, but current techniques are limited by force-based assumptions lack validation. objective this work was a subject-specific framework driven highly accurate knee kinematics as tool estimate vivo. First, repeatable testing system for simultaneous measurement pressures established. Measurements tibiofemoral translations rotations were with intraclass correlation coefficients greater than 0.98/0.90 0.80/0.97, respectively. pressure within 5.3% - 6.8%. Second, unique employing discrete element method combined developed using two cadaveric specimens. Model-generated stresses validated experimentally measured pressures. model predicted experimental data well, percent error (%) differences distribution being less 13%, validating model’s ability predict contact. Lastly, implemented group individuals osteoarthritis (n=5) control (n=6) during downhill walking task. patterns groups such that experienced (58%) lateral facet early phase gait cycle compared (38%). This dissertation has novel technique accurate, Future use these models provide quantitative evidence effectiveness solutions allow improved rehabilitation strategies.