Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily
作者： Bert van Loo , Christopher D. Bayer , Gerhard Fischer , Stefanie Jonas , Eugene Valkov
DOI: 10.1021/JACS.8B10290
关键词: Phylogenetic tree 、 Loss function 、 Sequence alignment 、 Enzyme 、 Phylogenetics 、 Hydrolase 、 Arylsulfatases 、 Chemistry 、 Alkaline phosphatase 、 Biochemistry
摘要: Highly proficient, promiscuous enzymes can be springboards for functional evolution, able to avoid loss of function during adaptation by their capacity to promote multiple reactions. We …
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rcsb.org参考文章(1)
Stefanie Jonas, Florian Hollfelder, Mechanism and Catalytic Promiscuity: Emerging Mechanistic Principles for Identification and Manipulation of Catalytically Promiscuous Enzymes Wiley‐VCH Verlag GmbH & Co. KGaA. pp. 47- 79 ,(2011) , 10.1002/9783527634026.CH3