Improving prediction fidelity of cellular metabolism with kinetic descriptions

摘要: Several modeling frameworks for describing and redirecting cellular metabolism have been developed keeping pace with the rapid development in high-throughput data generation advances metabolic engineering techniques. The incorporation of kinetic information within stoichiometry-only techniques offers potential advantages improved phenotype prediction consequently more precise computational strain design. In addition to substrate-level regulatory information, integration a number additional layers regulation at transcription, translation, post-translation levels is sought after by many research groups. However, practical these complex biological processes into unified framework amenable design remains an ongoing challenge.