Genetic and pharmacological approaches to preventing neurodegeneration
作者： Marco Boccitto , None
DOI:
关键词: Amyotrophic lateral sclerosis 、 Neuroprotection 、 Disease 、 FOXO3 、 Neurodegeneration 、 Mechanism of action 、 Neuroscience 、 Transcription factor 、 Mechanism (biology) 、 Biology
摘要: The Insulin/Insulin-like Growth Factor 1 Signaling (IIS) pathway was first identified as a major modifier of aging in C. elegans. It has since become clear that the ability of this pathway to …
参考文章(192)
Michał Mikula, Artur Dzwonek, Jakub Karczmarski, Tymon Rubel, Michał Dadlez, Lucjan S. Wyrwicz, Karol Bomsztyk, Jerzy Ostrowski, Landscape of the hnRNP K protein–protein interactome Proteomics. ,vol. 6, pp. 2395- 2406 ,(2006) , 10.1002/PMIC.200500632
H. Daitoku, M. Hatta, H. Matsuzaki, S. Aratani, T. Ohshima, M. Miyagishi, T. Nakajima, A. Fukamizu, Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 10042- 10047 ,(2004) , 10.1073/PNAS.0400593101
W. H. Biggs, J. Meisenhelder, T. Hunter, W. K. Cavenee, K. C. Arden, Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 7421- 7426 ,(1999) , 10.1073/PNAS.96.13.7421
Marta Artal-Sanz, Nektarios Tavernarakis, Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans Nature. ,vol. 461, pp. 793- 797 ,(2009) , 10.1038/NATURE08466
Itzhak Mano, Monica Driscoll, Caenorhabditis elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity. Journal of Neurochemistry. ,vol. 108, pp. 1373- 1384 ,(2009) , 10.1111/J.1471-4159.2008.05804.X
Muyang Li, Wei Gu, A critical role for noncoding 5S rRNA in regulating Mdmx stability. Molecular Cell. ,vol. 43, pp. 1023- 1032 ,(2011) , 10.1016/J.MOLCEL.2011.08.020
Vassilis E. Koliatsos, Richard E. Clatterbuck, John W. Winslow, Michelle H. Cayouette, Donald L. Prices, Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo Neuron. ,vol. 10, pp. 359- 367 ,(1993) , 10.1016/0896-6273(93)90326-M
Yoko Mochizuki, Toshio Mizutani, Toshio Shimizu, Akihiro Kawata, Proportional neuronal loss between the primary motor and sensory cortex in amyotrophic lateral sclerosis Neuroscience Letters. ,vol. 503, pp. 73- 75 ,(2011) , 10.1016/J.NEULET.2011.08.014
Martin Holzenberger, Joëlle Dupont, Bertrand Ducos, Patricia Leneuve, Alain Géloën, Patrick C. Even, Pascale Cervera, Yves Le Bouc, IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Nature. ,vol. 421, pp. 182- 187 ,(2003) , 10.1038/NATURE01298
Jelena Mojsilovic-Petrovic, Goo-Bo Jeong, Amanda Crocker, Amrita Arneja, Samuel David, David Russell, Robert G Kalb, Protecting Motor Neurons from Toxic Insult by Antagonism of Adenosine A2a and Trk Receptors The Journal of Neuroscience. ,vol. 26, pp. 9250- 9263 ,(2006) , 10.1523/JNEUROSCI.1856-06.2006