Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells.
作者： Stephen Shears , Francesca Granucci , Ivan Zanoni , Mariacristina Crosti , Francesca Mingozzi
DOI: 10.1126/SCISIGNAL.AAZ2120
关键词: Cell biology 、 Inositol trisphosphate receptor 、 NFAT 、 Phospholipase C 、 TLR4 、 Innate immune system 、 CD14 、 Inositol 、 Receptor complex 、 Chemistry
摘要: Innate immune responses to Gram-negative bacteria depend on the recognition of lipopolysaccharide (LPS) by a receptor complex that includes CD14 and TLR4. In dendritic cells …
sciencemag.org参考文章(75)
Andrew T. Miller, Carol Dahlberg, Mark L. Sandberg, Ben G. Wen, Daniel R. Beisner, John A. H. Hoerter, Albert Parker, Christian Schmedt, Monique Stinson, Jacqueline Avis, Cynthia Cienfuegos, Mark McPate, Pamela Tranter, Martin Gosling, Paul J. Groot-Kormelink, Janet Dawson, Shifeng Pan, Shin-Shay Tian, H. Martin Seidel, Michael P. Cooke, Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0131071
K Takazawa, J Perret, J E Dumont, C Erneux, Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme. Biochemical Journal. ,vol. 278, pp. 883- 886 ,(1991) , 10.1042/BJ2780883
Julie Helft, Jan Böttcher, Probir Chakravarty, Santiago Zelenay, Jatta Huotari, Barbara U. Schraml, Delphine Goubau, Caetano Reis e Sousa, GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells. Immunity. ,vol. 42, pp. 1197- 1211 ,(2015) , 10.1016/J.IMMUNI.2015.05.018
Andrew T. Miller, Daniel R. Beisner, Daorong Liu, Michael P. Cooke, Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction. Journal of Immunology. ,vol. 182, pp. 4696- 4704 ,(2009) , 10.4049/JIMMUNOL.0802850
G Guillemette, T Balla, A J Baukal, K J Catt, Characterization of inositol 1,4,5-trisphosphate receptors and calcium mobilization in a hepatic plasma membrane fraction. Journal of Biological Chemistry. ,vol. 263, pp. 4541- 4548 ,(1988) , 10.1016/S0021-9258(18)68817-9
James W. Putney, PLC-γ: an old player has a new role Nature Cell Biology. ,vol. 4, ,(2002) , 10.1038/NCB1202-E280
Patrick J. Shaw, Stefan Feske, Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity. The Journal of Physiology. ,vol. 590, pp. 4157- 4167 ,(2012) , 10.1113/JPHYSIOL.2012.233221
Helen S. Goodridge, Randi M. Simmons, David M. Underhill, Dectin-1 Stimulation by Candida albicans Yeast or Zymosan Triggers NFAT Activation in Macrophages and Dendritic Cells Journal of Immunology. ,vol. 178, pp. 3107- 3115 ,(2007) , 10.4049/JIMMUNOL.178.5.3107
Robert E. Hagar, Angela D. Burgstahler, Michael H. Nathanson, Barbara E. Ehrlich, Type III InsP3 receptor channel stays open in the presence of increased calcium Nature. ,vol. 396, pp. 81- 84 ,(1998) , 10.1038/23954
Murali Prakriya, Richard S. Lewis, Store-Operated Calcium Channels Physiological Reviews. ,vol. 95, pp. 1383- 1436 ,(2015) , 10.1152/PHYSREV.00020.2014