Rectal sequelae after conformal radiotherapy of prostate cancer: dose-volume histograms as predictive factors
作者： Stefan Wachter , Natascha Gerstner , Gregor Goldner , Regina Pötzi , Andre Wambersie
DOI: 10.1016/S0167-8140(01)00281-X
关键词: Prostate cancer 、 Dose-volume histogram 、 Predictive value of tests 、 Area under the curve 、 Colonoscopy 、 Radiation therapy 、 Nuclear medicine 、 Rectum 、 Medicine 、 Survival rate
摘要: Purpose: To identify clinically relevant parameters predictive of late rectal bleeding derived from cumulative dose-volume histograms (DVHs) the rectum after conformal radiotherapy prostate cancer. Materials and methods: One hundred nine patients treated with 3D between 1/1994 1/1996 for localized cancer (clinical stage T1-T3) were available analysis. All received a total dose 66 Gy/2 Gy per fraction (specified at International Commission on Radiation Units Measurements ICRU reference point). DVHs contoured analyzed by defining absolute (aV) relative (rV) volume that more than 30% (V-30), 50% (V-50), 70% (V-70) 80% (V-80), 90% (V-90) 100% (V-100) prescribed dose. Additionally, new aspect DVH analysis was investigated calculation area under DVH-curve several levels (area curve (AUC)-DVH). DVH-variables correlated radiation side effects evaluated in 3-6 months intervals graded according to EORTC/RTOG score. The median follow-up 30 (12-60 months). Results: Univariate multivariate stepwise Cox-Regression including age, PTV, size, rV(100), rV(90), rV(80), rV(70); rV(50) rV(30) aV(30), aV(100) calculated. Late (EORTC/RTOG grade 2) significantly percentage receiving greater or equal (rV(90)) (P = 0.007) inversely significant way size 0.006) In our series, proportion 57% included 90%-isodose (rV(90) 57%) one half patients, an actuarial incidence 31% 3 years. other when rV(90) < 57%, 3-year 11% 0.03). Conclusion: Our data demonstrate relationship 60 (similar dose) respect toxicity. seems be most useful easily obtained parameter comparing treatment plans evaluate risk morbidity. (C) 2001 Elsevier Science Ireland Ltd. rights reserved.
elsevier.com
sci-hub.se 参考文章(26)
Alan C. Hartford, Andrzej Niemierko, Judith A. Adams, Marcia M. Urie, William U. Shipley, Conformal irradiation of the prostate: Estimating long-term rectal bleeding risk using dose-volume histograms International Journal of Radiation Oncology Biology Physics. ,vol. 36, pp. 721- 730 ,(1996) , 10.1016/S0360-3016(96)00366-5
R I MacKay, J H Hendry, C J Moore, P C Williams, G Read, Predicting late rectal complications following prostate conformal radiotherapy using biologically effective doses and normalized dose-surface histograms British Journal of Radiology. ,vol. 70, pp. 517- 526 ,(1997) , 10.1259/BJR.70.833.9227235
L BOERSMA, M VANDENBRINK, A BRUCE, T SHOUMAN, L GRAS, A TEVELDE, J LEBESQUE, Estimation of the incidence of late bladder and rectum complications after high-dose (70-78 GY) conformal radiotherapy for prostate cancer, using dose-volume histograms. International Journal of Radiation Oncology Biology Physics. ,vol. 41, pp. 83- 92 ,(1998) , 10.1016/S0360-3016(98)00037-6
Marcel van Herk, Allison Bruce, A.P. Guus Kroes, Tarek Shouman, Adriaan Touw, Joos V. Lebesque, Quantification of organ motion during conformal radiotherapy of the prostate by three dimensional image registration International Journal of Radiation Oncology Biology Physics. ,vol. 33, pp. 1311- 1320 ,(1995) , 10.1016/0360-3016(95)00116-6
John C. Roeske, Jeffrey D. Forman, Carmen F. Mesina, Tony He, Charles A. Pelizzari, Ernesto Fontenla, S. Vijayakumar, George T.Y. Chen, Evaluation of changes in the size and location of the prostate, seminal vesicles, bladder, and rectum during a course of external beam radiation therapy International Journal of Radiation Oncology Biology Physics. ,vol. 33, pp. 1321- 1329 ,(1995) , 10.1016/0360-3016(95)00225-1
Alfred Tinger, Jeff M. Michalski, Abel Cheng, Daniel A. Low, Ron Zhu, Walter R. Bosch, James A. Purdy, Carlos A. Perez, A critical evaluation of the planning target volume for 3-D conformal radiotherapy of prostate cancer International Journal of Radiation Oncology Biology Physics. ,vol. 42, pp. 213- 221 ,(1996) , 10.1016/S0360-3016(98)00189-8
John T. Lyman, Complication Probability as Assessed from Dose-Volume Histograms Radiation Research. ,vol. 8, ,(1985) , 10.2307/3576626
R.K. Ten Haken, J.D. Forman, D.K. Heimburger, A. Gerhardsson, D.L. McShan, C. Perez-Tamayo, S.L. Schoeppel, A.S. Lichter, Treatment planning issues related to prostate movement in response to differential filling of the rectum and bladder. International Journal of Radiation Oncology Biology Physics. ,vol. 20, pp. 1317- 1324 ,(1991) , 10.1016/0360-3016(91)90244-X
Y. Lu, S. Li, D. Spelbring, P. Song, S. Vijayakumar, C. Pelizzari, G. T. Y. Chen, Dose-surface histograms as treatment planning tool for prostate conformal therapy. Medical Physics. ,vol. 22, pp. 279- 284 ,(1995) , 10.1118/1.597451
C. Burman, G.J. Kutcher, B. Emami, M. Goitein, Fitting of normal tissue tolerance data to an analytic function International Journal of Radiation Oncology Biology Physics. ,vol. 21, pp. 123- 135 ,(1991) , 10.1016/0360-3016(91)90172-Z