Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)

摘要: Abstract Two new anthraquinones, 1,3-dihydroxy-5-methoxy-6-methoxymethyl-2-methyl-9,10-anthraquinone ( 1 ) and 1,3-dihydroxy-5-methoxy-2,6-bismethoxymethyl-9,10-anthraquinone 2 ), together with ten known anthraquinone derivatives 3 – 12 three coumarin 13 15 6-gingerol 16 were isolated from the barks of Morinda citrifolia (Noni) collected in Yongxing island Xisha. The structures compounds 1–16 determined on basis extensive spectroscopic analyses, as well by comparison literature reports. tested for their antiviral, cytotoxic, antibacterial activities. In primary bioassays, displayed weak anti-H1N1 activity IC 50 values 66.1 10.5 μM, respectively. addition, compound showed anti-H3N2 value 11.5 μM, had antimicrobial against Staphylococcus aureus MIC 24.5 μM.