Generation of a concise gene panel for outcome prediction in urinary bladder cancer

摘要: C40 The primary clinical management of urothelial carcinoma (UC) the bladder is still based on TNM staging system that relies subjective pattern recognition and nomenclature for reporting specimens.The current need to complement UC with molecular correlates can accurately predict outcome while also acting as novel therapeutic targets. This study used standardized quantitative RT-PCR quantify absolute expressions 69 genes involved in crucial carcinogenic pathways relation a fixed quantity ACTB housekeeping gene frozen specimens from 58 subjects (stages Ta-T4) 5 normal controls. After log transformation expression levels, all tumor transcripts values beyond two standard deviations mean level urothelium were designated over or underexpressed, within normally expressed. By univariate log-rank analysis, STAT3, IGF1, JUN, SOD1, MAP2K6 (all P 3/4