Centrally mediated effect of phenytoin on digoxin-induced ventricular arrhythmias.

摘要: Studies on the efficacy of phenytoin administered directly into cerebrospinal fluid in protecting against digoxin-induced arrhythmias were carried out 20 anesthetized dogs. Phenytoin was an average dose 10 mg cisterna magna The other control dogs received only vehicle for intrathecally. Both groups subsequently a toxic digoxin (0.2 mg/kg) intravenously. time after intravenous to onset ventricular premature beats, tachycardia and fibrillation (VF) significantly shorter animals compared phenytoin-treated In group, one dog survived 3-h observation period without developing fibrillation, whereas 5 this VF (P less than 0.05). had similar protective effect that intrathecally, plasma concentrations undetectable. Thus, experimental model, exerts which is mediated via central nervous system.