Mechanisms of and perspectives on the mesenchymal stem cell in immunotherapy.
作者： Robert Chunhua Zhao , Lianming Liao , Qin Han
DOI: 10.1016/J.LAB.2003.11.009
关键词: Cancer research 、 Mesenchymal stem cell 、 Population 、 Immunotherapy 、 Transplantation 、 Immunology 、 Stem cell 、 Mechanism (biology) 、 Haematopoiesis 、 Cell 、 Medicine
摘要: Mesenchymal stem cells (MSCs) are an important cell population in the bone-marrow microenvironment and considered to be engaged mainly support of hematopoiesis. Recent work has shown that MSCs also have profound immunomodulatory function, both vitro vivo. Because can expanded rapidly numbers required for clinical application, several preclinical studies been performed areas immune diseases transplantation. In this review we discuss mechanisms underlying MSC's immunomodulating properties its potential applications.
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sci-hub.se 参考文章(52)
Yongan Li, Hiroko Hisha, Muneo Inaba, Zhexiong Lian, Chengze Yu, Masayo Kawamura, Yoshihisa Yamamoto, Nobuhiro Nishio, Junko Toki, Hongxue Fan, Susumu Ikehara, Evidence for migration of donor bone marrow stromal cells into recipient thymus after bone marrow transplantation plus bone grafts: A role of stromal cells in positive selection. Experimental Hematology. ,vol. 28, pp. 950- 960 ,(2000) , 10.1016/S0301-472X(00)00483-5
Fridenshteĭn AIa, None, Stromal bone marrow cells and the hematopoietic microenvironment Arkhiv patologii. ,vol. 44, pp. 3- 11 ,(1982)
M P Bell, S N Ho, J A Augustine, J J Ruegemer, R T Abraham, D J McKean, J W Schlager, Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression. Journal of Immunology. ,vol. 144, pp. 1767- 1776 ,(1990)
MD Mossalayi, F Mentz, F Ouaaz, AH Dalloul, C Blanc, P Debre, FW Ruscetti, Early human thymocyte proliferation is regulated by an externally controlled autocrine transforming growth factor-beta 1 mechanism Blood. ,vol. 85, pp. 3594- 3601 ,(1995) , 10.1182/BLOOD.V85.12.3594.BLOODJOURNAL85123594
PJ Simmons, B Torok-Storb, Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1 Blood. ,vol. 78, pp. 55- 62 ,(1991) , 10.1182/BLOOD.V78.1.55.55
Dimitrios T. Boumpas, Fotini Paliogianni, James E. Balow, Seema S. Ahuja, Hidehiro Yamada, Effect of transforming growth factor-beta on early and late activation events in human T cells. Journal of Immunology. ,vol. 150, pp. 3109- 3118 ,(1993)
Y Adachi, M Inaba, N Nagata, S Ikehara, H Hisha, T Ishida, R A Good, K Sugiura, R Ogawa, Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. Complete prevention of recurrence of autoimmune diseases in MRL/MP-Ipr/Ipr mice by transplantation of bone marrow plus bones (stromal cells) from the same donor. Journal of Immunology. ,vol. 152, pp. 3119- 3127 ,(1994)
Atsushi Asakura, Michael A. Rudnicki, Motohiro Komaki, Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation Differentiation. ,vol. 68, pp. 245- 253 ,(2001) , 10.1046/J.1432-0436.2001.680412.X
Xian Chang Li, Terry B. Strom, Laurence A. Turka, Andrew D. Wells, T Cell Death and Transplantation Tolerance Immunity. ,vol. 14, pp. 407- 416 ,(2001) , 10.1016/S1074-7613(01)00121-2
Graham Anderson, Eric J. Jenkinson, Nel C. Moore, John J. T. Owen, MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus Nature. ,vol. 362, pp. 70- 73 ,(1993) , 10.1038/362070A0