LncRNA LINC00511 Acts as an Oncogene in Colorectal Cancer via Sponging miR-29c-3p to Upregulate NFIA

摘要: Background Colorectal cancer (CRC), characterized by high mortality and incidence rate, is one of the most common types rectum tumors in gastrointestinal tract worldwide. An increasing number investigations indicated that long noncoding RNAs (lncRNAs) have been implicated growth a wide range cancers. Although it has obtained general acceptance lncRNA LINC00511 plays significant role numerous cancers, regulatory mechanism CRC still needs to be explored. Materials Methods Bioinformatics analysis experiments sphere formation assay, cell proliferation RT-qPCR, colony Transwell assay Western blot assays investigated function tissues cells. Results Our results manifested expression level was obviously upregulated cells accelerated development through facilitating proliferation, metastasis stemness. Molecular exploration uncovered acted as ceRNA competing with NFIA bind miR-29c-3p. Through rescue experiments, we discovered upregulation partly counteracted inhibitive effect induced silencing on progression. Conclusion These revealed participated progression targeting LINC00511/miR-29c-3p/NFIA axis, indicating may potential therapeutic target for treatment.