MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
作者： Iryna Kindrat , Volodymyr Tryndyak , Aline de Conti , Svitlana Shpyleva , Thilak K. Mudalige
关键词: Transferrin receptor 、 microRNA 、 Pathology 、 Cell culture 、 Biology 、 Cancer research 、 Transfection 、 Carcinogenesis 、 Carcinogen 、 2-Acetylaminofluorene 、 Hepatocellular carcinoma 、 Oncology
摘要: Over-expression of transferrin receptor 1 (TFRC) is observed in hepatocellular carcinoma (HCC); however, there a lack conclusive information regarding the mechanisms this dysregulation. In present study, we demonstrated significant increase levels TFRC mRNA and protein preneoplastic livers from relevant experimental models human hepatocarcinogenesis HCC cells. Additionally, using TCGA database, an over-expression tissue samples markedly decreased level microRNA-152 (miR-152) when compared to non-tumor liver tissue. The results indicated that cells may be attributed, part, post-transcriptional mechanism mediated by down-regulation miR-152. This was evidenced strong inverse correlation between expression miR-152 (r = -0.99, p 4. 7 × 10-9), confirmed vitro experiments showing transfection cell lines with effectively suppressed expression. suggests miR-152-specific targeting provide selective anticancer therapeutic approach for treatment HCC.
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