Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats
作者： M. Romkes , J. Piskorska-Pliszczynska , S. Safe
DOI: 10.1016/0041-008X(87)90292-4
关键词: Endocrinology 、 In utero 、 Toxicity 、 Receptor 、 Microgram 、 Internal medicine 、 Estrogen 、 Carcinogen 、 Uterus 、 Estrogen receptor 、 Biology 、 Toxicology 、 Pharmacology
摘要: Administration of a single dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 20 or 80 micrograms/kg) resulted in significantly decreased hepatic and uterine estrogen receptor (ER) levels 25-day-old female Long-Evans rats. By contrast, estradiol (5 15 administration increased ER levels, while combination 2,3,7,8-TCDD plus which were similar lower than those observed after treatment with only 2,3,7,8-TCDD. In addition, the effects on wet weight increase. Competitive binding studies showed that did not bind to aryl hydrocarbon (Ah) ER. The structure activity polychlorinated dibenzo-p-dioxin congeners their down-regulate determined by using 2,3,7,8-TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 1,3,7,8-TCDD, 1,2,4,7,8-PeCDD. Both 1,2,3,7,8-PeCDD exhibit high affinities for Ah at micrograms/kg 42 41%, respectively, 53 49%, respectively. 1,3,7,8-TCDD 1,2,4,7,8-PeCDD less avidly 400 these compounds 36 40%, 21 24%, These results support role down-regulation rat this effect may be associated decrease spontaneous mammary tumors rats treated
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