Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia

摘要: IT HAS been shown that various foods — for example, beef skeletal muscle,1 milk2 and eggs3 —contain a heat-stable, unidentified substance,4 the so-called extrinsic factor. When such source of factor as muscle is ingested by patient with pernicious anemia, untreated or in relapse, it produces little no hematopoietic effect unless normal human gastric juice also administered, either simultaneously at least within six hours.5 The very small amount secretion anemia thus apparently supplies none heat-labile substance, possibly an enzyme,6 7 8 responsible . . .