Cardiac hypertrophy due to pressure and volume overload: distinctly different biological phenomena?

摘要: Myocardial hypertrophy is a morphological adaptive response to chronic work overload imposed on the heart. It has been categorized into two distinct basic types: concentric hypertrophy, occurring in sustained pressure which wall thickness increases without chamber enlargement, and eccentric volume enlarges relative increase its thickness. should be emphasized, this context, that these adjectives are somewhat confusing, since observed not fashion often seen left ventricle of patients with hypertrophic cardiomyopathy. In fact, both instances, but associated an when described as eccentric, yet maintained said concentric. rats made anemic by iron deficiency, overloaded heart achieves mass characterized setting dilated ventricle. This so-called depends catecholamines possible signals for myocardial growth, progresses preserved ultrastructure contractile performance cardiac muscle. A gradually results harmonious growth (it retains normal shape, becoming magnified heart), probably mediated release myocardium. process resembles obligatory load increasing output (greater metabolic demands) blood volume.(ABSTRACT TRUNCATED AT 250 WORDS)